NS3

ORF3a protein

Función

Biological Process

Molecular Function/s

Localización Celular

Keywords Uniprot

DBIdentificador
UnipAcc Q7TLD0
Proteomes UP000131569
EMBL AY323977
DIP DIP-61251N
UnipAcc Q7TFB0
Proteomes UP000138690
UnipAcc P59632
SMR P59632
IntAct P59632
EMBL AY278741
EMBL AY463059
EMBL AY427439
EMBL AY278491
EMBL AP006561
GlyGen P59632
EMBL AY278490
EMBL AY274119
Proteomes UP000137377
UnipAcc Q7TA18
Proteomes UP000145651
EMBL AP006559
Proteomes UP000121636
EMBL AY291315
EMBL AY278554
iPTMnet P59632
EMBL AY278488
Proteomes UP000146181
Proteomes UP000146108
Proteomes UP000172416
BioGRID 4383917
UnipAcc Q80BV5
EMBL AP006560
PRIDE P59632
EMBL AY278487
Proteomes UP000103670
EMBL AP006557
GeneID 1489669
Proteomes UP000131955
UnipAcc Q7T6R6
Proteomes UP000164441
Pfam PF11289
KEGG vg:1489669
Proteomes UP000148194
EMBL AY322207
UnipAcc Q7TA10
EMBL AY291451
EMBL AY282752
RefSeq NP_828852.2
Proteomes UP000146296
EMBL AY278489
Proteomes UP000109640
EMBL AP006558
Proteomes UP000000354
EMBL AY338174
TCDB 1.A.57.1.1
Proteomes UP000153467
Proteomes UP000143093
EMBL AY310120
SIGNOR P59632
EMBL AY279354
Proteomes UP000116947
InterPro IPR024407
EMBL AY338175
UnipAcc AP3A_SARS
Proteomes UP000160648
EMBL AY348314

Anotación

Tipo Identificador InicioFin
chain ORF3a protein (PRO_0000106131) 1 274
topological domain Extracellular 1 34
transmembrane region Helical 35 55
topological domain Cytoplasmic 56 78
transmembrane region Helical 79 99
topological domain Extracellular 100 104
transmembrane region Helical 105 125
topological domain Cytoplasmic 126 274
compositionally biased region Poly-Leu 83 86
compositionally biased region Poly-Thr 267 270
Other site of interest Involved in polymerization 133 133
glycosylation site O-linked (GalNAc...) serine; by host () 27 27
glycosylation site O-linked (GalNAc...) threonine; by host () 28 28
glycosylation site O-linked (GalNAc...) threonine; by host () 32 32
glycosylation site O-linked (GalNAc...) threonine; by host () 34 34
Sequence variation in strain: Isolate Tor2, Isolate BJ02 and Isolate BJ03 () 11 11
Sequence variation in strain: Isolate Shanghai LY () 20 20
Sequence variation in strain: Isolate Shanghai QXC1 () 29 29
Sequence variation in strain: Isolate HKU-39849 () 101 101
Sequence variation in strain: Isolate TWK () 129 129
Sequence variation in strain: Isolate BJ01 () 136 136
Sequence variation in strain: Isolate GD01 () 171 171
Sequence variation in strain: Isolate GD01 () 193 193
Sequence variation in strain: Isolate Shanghai QXC1 () 222 222
mutagenesis site Complete loss of O-glycosylation; when associated with A-28; A-3 27 27
mutagenesis site Complete loss of O-glycosylation; when associated with A-27; A-3 28 28
mutagenesis site Complete loss of O-glycosylation; when associated with A-27; A-2 32 32
mutagenesis site Complete loss of O-glycosylation; when associated with A-27; A-2 34 34
mutagenesis site No effect on polymerization. 81 81
mutagenesis site No effect on polymerization. 117 117
mutagenesis site No effect on polymerization. 121 121
mutagenesis site No effect on polymerization. 127 127
mutagenesis site No effect on polymerization. 130 130
mutagenesis site Almost complete loss of polimerization ability. 133 133
mutagenesis site No effect on polymerization. 148 148
mutagenesis site No effect on polymerization. 157 157
chain ORF3a protein (PRO_0000106131) 1 274
topological domain Extracellular 1 34
transmembrane region Helical 35 55
topological domain Cytoplasmic 56 78
transmembrane region Helical 79 99
topological domain Extracellular 100 104
transmembrane region Helical 105 125
topological domain Cytoplasmic 126 274
compositionally biased region Poly-Leu 83 86
compositionally biased region Poly-Thr 267 270
Other site of interest Involved in polymerization 133 133
glycosylation site O-linked (GalNAc...) serine; by host () 27 27
glycosylation site O-linked (GalNAc...) threonine; by host () 28 28
glycosylation site O-linked (GalNAc...) threonine; by host () 32 32
glycosylation site O-linked (GalNAc...) threonine; by host () 34 34
Sequence variation in strain: Isolate Tor2, Isolate BJ02 and Isolate BJ03 () 11 11
Sequence variation in strain: Isolate Shanghai LY () 20 20
Sequence variation in strain: Isolate Shanghai QXC1 () 29 29
Sequence variation in strain: Isolate HKU-39849 () 101 101
Sequence variation in strain: Isolate TWK () 129 129
Sequence variation in strain: Isolate BJ01 () 136 136
Sequence variation in strain: Isolate GD01 () 171 171
Sequence variation in strain: Isolate GD01 () 193 193
Sequence variation in strain: Isolate Shanghai QXC1 () 222 222
mutagenesis site Complete loss of O-glycosylation; when associated with A-28; A-3 27 27
mutagenesis site Complete loss of O-glycosylation; when associated with A-27; A-3 28 28
mutagenesis site Complete loss of O-glycosylation; when associated with A-27; A-2 32 32
mutagenesis site Complete loss of O-glycosylation; when associated with A-27; A-2 34 34
mutagenesis site No effect on polymerization. 81 81
mutagenesis site No effect on polymerization. 117 117
mutagenesis site No effect on polymerization. 121 121
mutagenesis site No effect on polymerization. 127 127
mutagenesis site No effect on polymerization. 130 130
mutagenesis site Almost complete loss of polimerization ability. 133 133
mutagenesis site No effect on polymerization. 148 148
mutagenesis site No effect on polymerization. 157 157

Secuencia AA

Contexto Génico

Variantes

PosRefAltPaísesInfo.
16 K M Argentina:1 Mapeado en 0 estructuras.
21 K R Argentina:1 Mapeado en 0 estructuras.
22 D Y Argentina:1 Mapeado en 0 estructuras.
23 A S Argentina:1 Mapeado en 0 estructuras.
24 T I Argentina:1 Mapeado en 0 estructuras.
44 G R Argentina:1 Mapeado en 0 estructuras.
47 I V Argentina:1 Mapeado en 0 estructuras.
49 G V Argentina:2 Mapeado en 0 estructuras.
52 L F Argentina:2 Mapeado en 0 estructuras.
57 Q H Argentina:260 Mapeado en 0 estructuras.
90 V F Argentina:1 Mapeado en 0 estructuras.
110 A G Argentina:7 Mapeado en 0 estructuras.
110 A V Argentina:3 Mapeado en 0 estructuras.
128 W L Argentina:1 Mapeado en 0 estructuras.
134 R L Argentina:1 Mapeado en 0 estructuras.
136 K Q Argentina:1 Mapeado en 0 estructuras.
166 S L Argentina:1 Mapeado en 0 estructuras.
171 S L Argentina:17 Mapeado en 0 estructuras.
202 V L Argentina:1 Mapeado en 0 estructuras.
244 V I Argentina:2 Mapeado en 0 estructuras.
251 G V Argentina:46 Mapeado en 0 estructuras.
254 G * Argentina:3 Mapeado en 0 estructuras.